Illarioshkin Sergey Nikolaevich

Deputy Director for Research
D. Sci. (Med.), Professor
Corresponding Member of Russian Academy of Sciences

Education and Titles

1980-1986 – Student, I.M. Sechenov First Moscow Medical Institute, Faculty of medicine, Moscow, Russia
1986-1988 – Resident, Research Center of Neurology, Moscow, Russia
1988-1991 – PhD Student Research Center of Neurology, Moscow, Russia. 1992 Thesis “Phenotypic polymorphism and the role of mediator amino acids in hereditary spinocerebellar degenerations”
1997 – Doctor’s degree thesis: “Hereditary monogenic diseases of the nervous system: molecular analysis and clinical-genetic comparisons”
1993, 1995-1996 – Scientific internship on the molecular genetics of hereditary human diseases in the Department of Neurology, Institute of the Brain of the University, Niigata, Japan
1998, 1999 – Scientific internship in the Department of Pathology of Neurons, National Institute of Health and Medical Research of France (INSERM), based on the Hôpital universitaire Pitié-Salpêtrière (Paris)
2003 – Professor of Neurology
2016 – Corresponding Member of Russian Academy of Sciences

Career

1996-2003 – Senior, then Leading Research Assistant of the Neurogenetic Department, Research Center of Neurology;
1996-2003 – Academic secretary, Research Center of Neurology;
1996-2006 – Head of the DNA laboratory, Research Center of Neurology;
2003-present – Deputy Director for Research, Research Center of Neurology;
2004-2012 – Deputy chairman of the Bureau of the Scientific Council for Neurology of the RAMS and the Ministry of Health and Social Development of Russia;
2006-2022 – Head of the Brain Research Department, Research Center of Neurology;
2022-present – Head of the Brain Institute, Research Center of Neurology.

Additional information

2007-present – Vice-president of the European Federation of Neurological Societies (EFNS) and the European Agency of Neurology (EAN);
2009-present – President of the Russian National Society for the Study of Parkinson’s Disease and Movement Disorders;
2014-present – Deputy chairman of the Dissertation Council;
2014-2016 – Member of the Expert Council for the Therapeutic Sciences of the Higher Attestation Commission of the Ministry of Education and Science of Russia;
2016 -present – Member of the Presidium of the Higher Attestation Commission of the Ministry of Education and Science of Russia;
Member of the Presidium of the Board of the Russian Society of Medical Genetics;
Board Member of the Russian Society of Neurologists;
President of the National Society for the Study of Parkinson’s Disease and Movement Disorders;
Coordinator of the Russian section of the European Huntington’s Disease Network (Euro-HD Network);
Member of the Management Committee of the European Commission of the Movement Disorders Society (MDS) for continuous dopaminergic stimulation;
Deputy Editor-in-Chief of the journal “Annals of Clinical and Experimental Neurology”;
Editor-in-Chief of the journal “Nervous Diseases”;
Editor-in-Chief of the Bulletin of the National Society for the Study of Parkinson’s Disease and Movement Disorders;
Member of the Editorial Board of journals: “Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova” “Neurological Journal,” “Medical Genetics”.

Scientific Interests

Parkinson’s disease and other neurodegenerative diseases (analysis of the molecular basis of development and progression, development of new methods of diagnosis, treatment and prevention);
Hereditary diseases of the central nervous system (pathogenesis, molecular genetics, analysis of phenotypic polymorphism, diagnosis, development of new methods of treatment and prevention)
Gene and Cell Therapy;
Mapping of genes, mutation analysis and development of DNA diagnostics of hereditary monogenic psychoneurological diseases;
Investigation of molecular neurophysiological and neurochemical mechanisms of brain plasticity in healthy individuals and in various types of pathological processes;
Mechanisms of brain aging;
Experimental neurology.

Illarioshkin S.N. is the author of 688 publications, including 12 monographs and manuals, 22 chapters in manuals, 6 tutorials, 13 patents for inventions.

Most cited works

Identical dysferlin mutation in limb-girdle muscular dystrophy type 2B and distal myopathy

Illarioshkin, S.N., Ivanova-Smolenskaya, I.A.,Greenberg, C.R. et al. Identical dysferlin mutation in limb-girdle muscular dystrophy type 2B and distal myopathy. Neurology. 2000;
Periquet, M.,Lücking (…), Illarioshkin S.N. et al. Origin of the mutations in the parkin gene in Europe: Exon rearrangements are independent recurrent events, whereas point mutations may result from founder effects. American Journal of Human Genetics. 2001;
Illarioshkin, S.N.,Igarashi, S.,Onodera, O. Trinucleotide repeat length and rate of progression of Huntington’s disease. Annals of Neurology. 1994;
Illarioshkin, S.N.,Ivanova-Smolenskaya, I.A.,Tanaka, H. et al. Clinical and molecular analysis of a large family with three distinct phenotypes of progressive muscular dystrophy. Brain.1996;
Boldyrev, A.,Fedorova, T.,(…) Illarioshkin, S. Carnisone increases efficiency of DOPA therapy of Parkinson’s disease: A pilot study. Rejuvenation Research. 2008;
Illarioshkin, S.N.,Ivanova-Smolenskaya, I.A.,Rahmonov, R.A. et al. Alcohol dehydrogenase alleles in Parkinson’s disease. Movement Disorders. 2000;
Illarioshkin, S.N.,Tanaka, H.,Markova, E.D. et al. X-linked nonprogressive congenital cerebellar hypoplasia: Clinical description and mapping to chromosome Xq. Annals of Neurology. 1996;
Shadrina, M.I.,Semenova, E.V.,(…) Illarioshkin, S.N. et al. Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1-12 dosage. BMC Medical Genetics. 2007;
Slominsky, P.A.,Markova, E.D., (…) Illarioshkin, S.N. et al. A common 3-bp deletion in the DYT1 gene in Russian families with early-onset torsion dystonia. Human mutation.1999;
Ivanova-Smolenskaya, I.A.,Ovchinnikov I.V. (…) Illarioshkin, S.N. The His1069Gln mutation in the ATP7B gene in Russian patients with Wilson disease [3]. Journal of Medical Genetics. 1999;
Stelmashook, E.V.,Isaev, N.K. (…) Illarioshkin, S.N. Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases. Biochemistry (Moscow). 2014;
Illarioshkin, S.N.,Periquet, M.,Rawal, N. Et al. Mutation analysis of the parkin gene in Russian families with autosomal recessive juvenile parkinsonism. Movement Disorders. 2003.

Educational work

1998 – present. Professor, Research Center of Neurology.
2005 – present. Professor (Neurology), Faculty of Fundamental Medicine, Lomonosov Moscow State University.

S.N. Illarioshkin guided 3 Doctoral and 18 PhD thesis.